International Review of Ophthalmology

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Progress of epigenetics study in the pathogenesis of myopia

ZHANG Chu, ZHU Zi-cheng, ZHAN Xin, YING Chong-hui   

  1. Department of Ophthalmology, Provincial Hospital Affiliated of Anhui Medical University, The First Affilated Hospital of University of Science and Technology of China, Hefei 230001, China
  • Received:2018-03-18 Online:2018-12-22 Published:2018-12-22
  • Contact: ZHU Zi-cheng，Email：zczhu123@163.com
  • Supported by:

    Anhui Natural Science Foundation（1508085MH188）；Education Department of Anhui Province Teaching Research Project（2016jyxm0546）

Abstract:

The pathogenesis of myopia is unclear. Genetic and environmental factors may play an important role.  Recent studies in epigenetics have promoted the understanding of the pathogenesis of myopia. Epigenetics includes DNA methylation, histone modification and non-coding RNA. DNA methylation in the promoter region CpG island and changes in the expression of some miRNAs may be involved in the progression of myopia. (Int Rev Ophthalmol, 2018, 42:   393-395)